RavenBiotech Inc.- On line methanol monitoring and control in Pichia pastoris fermentation - Technology References

References

Effects of methanol concentration on expression levels of recombinant protein in fed-batch cultures of Pichia methanolica.
Brian E. Mayson, Douglas G. Kilburn, Bruce L. Zamost, Christopher K. Raymond, Gary J. Lesnick.
Biotechnology and Bioengineering
Volume: 81, Issue: 3, Date: 5 February 2003, Pages: 291-298.

Fermentation strategies for improved heterologous expression of Iaccase in Pichaia pastoris.
Feng Hong, Nina Q. Meinander, Leif Jönsson
Biotechnology and Bioengineering
Volume: 79, Issue: 4, Date: 20 August 2002, Pages: 438-449.

On-Line monitoring and control of methanol concentration in shake-flask cultures of Pichia pastoris.
M.M. Guarna, G.J. Lesnicki, B.M. Tam, J. Robinson, C.Z. Radziminski, D. Hasenwinkle, A. Boraston, E. Jervis, R.T.A. MacGillivray, R.F.B. Turner, D.G. Kilburn
Biotechnology and Bioengineering
Volume: 56, Issue: 3, Date: 5 November 1997, Pages: 279-286.

Control, Coordination Help Scale Up New Enzymes
Optimizing Fermentation in Its Pilot Plant, and Working Closely With Its Contract Partner, Diversa Has Increased Yield Five-fold, and Reduced Costs by 75%
http://www.pharmamanufacturing.com/articles/2004/127.html

GMP production and characterization of the bivalent anti-human T cell immunotoxin, A-dmDT390-bisFv(UCHT1) for phase I/II clinical trials
Jung Hee Woo et al

Cyclic fed-batch culture for production of human serum albumin in Pichia pastoris
M. E. Bushell et al

Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures
Shweta Singh et al

Specificity Determinants of Human Cathepsin S Revealed by Crystal Structures of Complexes
Thomas A. Pauly, et al

An optimized fermentation process for high-level production of a single-chain Fv antibody fragment in Pichia pastoris
Leonardo M. Damasceno et al

Received 1 December 2003;
Revised 9 March 2004.
Available online 7 July 2004..